@article{bibcite_36495, author = {Tuhin K Poddar and Corinne D Scown}, title = {Technoeconomic analysis for near-term scale-up of bioprocesses}, abstract = {

Growing the bioeconomy requires products and pathways that are cost-competitive. Technoeconomic analyses (TEAs) aim to predict the long-term economic viability and often use what are known as nth plant cost and performance parameters. However, as TEA is more widely adopted to inform everything from early-stage research to company and investor decision-making, the nth plant approach is inadequate and risks being misused to inform the early stages of scale-up. Some methods exist for conducting first-of-a-kind/pioneer plant cost analyses, but these receive less attention and have not been critically evaluated. This article explores TEA methods for early-stage scale-up, critically evaluates their applicability to biofuels and bioproducts, and recommends strategies for producing TEA results better suited to guiding prioritization and successful scale-up of bioprocesses.

}, year = {2025}, booktitle = {Current Opinion in Biotechnology}, journal = {Current Opinion in Biotechnology}, series = {Current Opinion in Biotechnology}, volume = {92}, pages = {103258}, month = {04/2025}, institution = {Elsevier BV}, publisher = {Elsevier BV}, issn = {0958-1669}, url = {https://doi.org/10.1016/j.copbio.2025.103258}, doi = {10.1016/j.copbio.2025.103258}, }