@article{30679,
  author = {Bo Hang and Yunshan Wang and Yurong Huang and Pin Wang and Sasha A Langley and Lei Bi and Altaf H Sarker and Suzaynn F Schick and Christopher Havel and Peyton Jacob III and Neal L Benowitz and Hugo Destaillats and Xiaochen Tang and Yankai Xia and Kuang-Yu Jen and Lara A Gundel and Jian-Hua Mao and Antoine M Snijders},
  title = {Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice},
  abstract = {<p>Exposure to thirdhand smoke (THS) is a recently described health concern that arises in many indoor environments. However, the carcinogenic potential of THS, a critical consideration in risk assessment, remains untested. Here we investigated the effects of short-term early exposure to THS on lung carcinogenesis in A/J mice. Forty weeks after THS exposure from 4 to 7 weeks of age, the mice had increased incidence of lung adenocarcinoma, tumor size and, multiplicity, compared with controls. <em>In vitro</em> studies using cultured human lung cancer cells showed that THS exposure induced DNA double-strand breaks and increased cell proliferation and colony formation. RNA sequencing analysis revealed that THS exposure induced endoplasmic reticulum stress and activated p53 signaling. Activation of the p53 pathway was confirmed by an increase in its targets p21 and BAX. These data indicate that early exposure to THS is associated with increased lung cancer risk.</p>},
  year = {2018},
  journal = {Clinical Science},
  volume = {132},
  pages = {475-488},
  month = {02/2018},
  doi = {10.1042/CS20171521},
  language = {eng},
}