@article{663, keywords = {Automation, X-Ray, Crystallography, Macromolecular Substances, X-Ray: methods}, author = {Anubhav Jain and Vivian Stojanoff}, title = {Are you centered? An automatic crystal-centering method for high-throughput macromolecular crystallography}, abstract = {
Crystal centering is a key step in macromolecular X-ray crystallography experiments. A new method using image-processing and machine-vision techniques allows the centering of small crystals in the X-ray beam. This method positions crystals even when the loop is initially out of the camera{\textquoteright}s field of view and adapts to the difficulty of the experiment. The process has been tested on many diverse crystals with a 93\% success rate when compared with manual centering.
}, year = {2007}, booktitle = {Journal of synchrotron radiation}, journal = {Journal of synchrotron radiation}, series = {Journal of synchrotron radiation}, volume = {14}, pages = {355-60}, month = {07/2007}, doi = {10.1107/S0909049507018110}, language = {eng}, }