@article{22192,
  keywords = {Multimedia models, Human toxicity potential, InLCA, Life-cycle impact, Model performance, Model uncertainty, Uncertainty, Variability},
  author = {Thomas E McKone and Edgar G Hertwich},
  title = {The Human Toxicity Potential and a Strategy for Evaluating Model  Performance in Life-Cycle Impact Assessment},
  abstract = {<p>The Human Toxicity Potential (HTP) is a quantitative toxic equivalency potential (TEP) that has been introduced previously to express the potential harm of a unit of chemical released into the environment. HTP includes both inherent toxicity and generic source-to-dose relationships for pollutant emissions. Three issues associated with the use of HTP in life-cycle impact assessment (LCIA) are evaluated here. First is the use of regional multimedia models to define source-to-dose relationships for the HTP. Second is uncertainty and variability in source-to-dose calculations. And third is model performance evaluation for TEP models. Using the HTP as a case study, we consider important sources of uncertainty/variability in the development of source-to-dose models—including parameter variability/uncertainty, model uncertainty, and decision rule uncertainty. Once sources of uncertainty are made explicit, a model performance evaluation is appropriate and useful and thus introduced. Model performance evaluation can illustrate the relative value of increasing model complexity, assembling more data, and/or providing a more explicit representation of uncertainty. This work reveals that an understanding of the uncertainty in TEPs as well as a model performance evaluation are needed to a) refine and target the assessment process and b) improve decision making.</p>},
  year = {2001},
  journal = {International Journal of Life-Cycle Assessment},
  volume = {6},
  number = {2},
  pages = {106-109},
  month = {03/2001},
  issn = {0948-3349},
  doi = {10.1007/BF02977846},
  language = {eng},
}